Abstract: OBJECTIVE To develop a colon-targeted capsule to achieve targeted release in colon of indometacin. METHODS The insoluble semi-permeable capsule body was prepared by dipping-drying process. After filling with drugs, the capsule body were stuffed by pectin tablet. The insoluble body was capped into a stomach-soluble capsule, following with the enteric coating outside the capsule. Then in vitro release was investigated. RESULTS The system was undeformed and no drug released in artificial gastric fluid. The indometacin capsule made of PEG-2 000∶CA 60% insoluble capsule body, coating weight gain 90% and drugs：NaCl 1∶1, reached to colon specific release completely, with drugs released <10% in artificial intestinal juice in 3 h, and >70% in artificial colonal juice in 10 h. CONCLUSION The indomethacin colon-targeted capsule can realize releasing drugs in the colon target position.