Abstract: OBJECTIVE To optimize the extractive technology of Jiangtangyihao capsule. METHODS Water reflux, extraction time, extraction times and solid-liquid ratio were observed as factors, total flavonoids was investigated as the indicator. Box-Behnken design-response surface methodology was used to analyze test data. RESULTS Extraction time and the number of extraction times had a very significant impact on the experimental results and the solid-liquid ratio had a significant impact on the test results. The optimum extraction conditions for Jiangtangyihao capsule were obtained as follows: extracting three times with water reflux extraction, each time was 59 min, the ratio of solid-liquid was 23 mL·g^-1. Relative deviation between the measured yield of flavonoids and predicted total yield of flavonoids was -2.66%. CONCLUSION The extraction method was accurate, rational and feasible.