Abstract: OBJECTIVE To evaluate the medicinal effect of different processing products of Notoginseng Radix et Rhizome on animal model of blood-deficiency, and to make comparison of blood-enriching effect among those products to screen out the optimal product. METHODS The 2% acetyl phenyl hydrazine solution was subcutaneously injected into rats for establishing the blood-deficiency model. Each group were separately treated with different processing product of Notoginseng Radix et Rhizome by oral administration. Donkey-hide gelatin was used in the positive control group. The parameters of facial rectal-temperature, complete blood count (CBC), blood microcirculation, and blood coagulation time/bleeding time were estimated. RESULTS The aqueous and ethanol extracte of steamed Notoginseng Radix et Rhizoma could significantly improve the rat blood microcirculation(P<0.01); the aqueous extract could raise the rat RBC and HCT(P<0.01), decrease blood coagulatio time(P<0.05); the ethanol extract could raise facial and rectal temperature(P<0.05). The aqueous extracte of fried Notoginseng Radix et Rhizoma could significantly raise RBC, HCT, facial and rectal temperature(P<0.01); the ethanol extracte of fried Notoginseng Radix et Rhizoma could also raise facial temperature, and improve the rat blood microcirculation(P<0.05). The aqueous and ethanol extracte of raw product Notoginseng Radix et Rhizoma could significantly significantly decrease blood coagulatio time/bleeding time(P<0.01 or P<0.05); the aqueous extract could raise the rat RBC(P<0.05); the ethanol extract could improve the rat blood microcirculation(P<0.05). CONCLUSION The processing products of Notoginseng Radix et Rhizome has better effect of blood-enriching than the raw product, but has no better effect in the blood coagulation time/bleeding time.