Abstract: OBJECTIVE To explore the effect of ginseng polysaccharide on hypertrophic myocardium and energy metabolism caused by abdominal aorta constriction(AAC) in rats. METHODS Myocardial hypertrophy model in 50 rats was established by AAC and randomly divided into Sham group, AAC group, and ginseng polysaccharide 200, 100, 50 mg·kg-1 groups. Receiving therapy for 11 weeks, heart mass index(HMI) and left ventricular mass index(LVMI) were detected. Pathological section was observed by HE staining. The expression of mRNA of atrial natriuretic peptide(ANP) was observed by RT-PCR. Lactic acid(LAC) and free fatty acids(FFA) were measured by ultraviolet spectrophotometry. Mitochondrial membrane potential(MMP) was detected by laser confocal microscopy. RESULTS Compared with sham group, MMP significantly decreased and other indicators significantly elevated in AAC group. Compared with AAC group, ginseng polysaccharide groups reduced expression of HMI, LVMI, ANP mRNA, FFA and LAC(P<0.01 or P<0.05) and rised MMP level(P<0.01 or P<0.05). CONCLUSION Ginseng polysaccharide significantly improves myocardial energy metabolism in AAC rats and protects the function of myocardial mitochondria.