Abstract: OBJECTIVE To observe the curative effect of cream friction combined with ultrasonic drug penetration for treating cervicogenic shoulder pain and to observe the related effective factors regulation change. METHODS Randomly divide 96 patients suffering from cervicogenic shoulder and back pain into two groups, in which 48 patients were in treatment group, the other 48 patients in control group. Adopt cream friction combined with ultrasonic drug penetration for treatment group, and regular manipulation combined with oral administration of celecoxib capsules for control group. Observe effect and concentration change of these related inflammatory factors such as IL-1β receptor antagonist, IL-6 and TNF before and after treatment respectively. And estimate clinical effect based on reference standard. RESULTS After treatment, the concentration of IL-1β receptor antagonist in both groups increased, while in treatment group, it was more obvious; and the concentration of IL-6 in blood plasm in both groups decreased, while in treatment group, it was more obvious. TNF concentration in blood plasm in both groups decreased, while in treatment group, it was more obvious. In terms of clinical effect rate, the treatment group was 91.7%, control group was 75%. Therefore, treatment group was better than control group(P<0.05). CONCLUSION Cream friction combined with ultrasonic drug penetration is effective method to treat cervicogenic shoulder and back pain, which is more effective than regular manipulation combined with oral drugs. The former method can regulate IL-1, IL-6 and TNF concentration in blood plasm.