Abstract: OBJECTIVE To compare analgesic effect of Corydalis yanhusuo decoction pieces by two processing technology: processing integration and traditional processing. METHODS By applying the hot plate, writhing body and tail-immersion test methods in mice, experiments were performed to observe analgesic effect of Corydalis yanhusuo decoction pieces by the two different processing technology. RESULTS The mice's pain threshold caused by hot board was improved by Corydalis yanhusuo decoction pieces both by the two processing technology, there were significant differences compared with normal saline groups(P<0.05). The analgesia effect of Corydalis yanhusuo decoction pieces by processing integration was superior to the traditional processing, the difference was statistically significant(P<0.05). CONCLUSION Corydalis yanhusuo decoction pieces by processing integration has analgesic effect which is superior to that by traditional processing.