Abstract: This paper reviewed the adverse reactions and prevention countermeasures of beta-blockers treatment for infantile hemangiomas. A search in PubMed, Medline, EMBASE/EM, IPA, CNKI and etc electronic database for all articles about adverse reactions in clinical trails of the beta-blockers treatment for infantile hemangiomas from May 2008 to September 2012 was conducted. This review could provide reference for clinical applications and development of new drug to promote rational use and clinical safety of the drug and then offer basis for the development of new indication and new formulation of beta-blockers.