N-杂环卡宾催化的成环反应研究进展

Process in N-Heterocyclic Carbene-Catalyzed Annulation Reactions

摘要: 目的介绍N-杂环卡宾催化的成环反应研究进展。方法综合国内外报道的文献，阐述N-杂环卡宾催化的成环反应。结果列出了N-杂环卡宾催化的分子内Stetter反应、亲核取代反应、环加成反应和串联反应等成环方法，重点分析了N-杂环卡宾催化的4+2，3+2，2+2和3+3环加成合成法。结论 N-杂环卡宾催化成环反应的发展在有机合成方法学中为高效成环提供了新的途径和策略。

Abstract: OBJECTIVE To introduce the process in N-heterocyclic carbene-catalyzed annulation reactions. METHODS To review both domestic and international published reports regarding N-heterocyclic carbene-catalyzed annulation reactions. RESULTS To make a list of N-heterocyclic carbene-catalyzed annulation reactions of intramolecular Stetter reaction, nucleophilic substitution reaction, cycloaddition and tandem reaction and to analyze N-heterocyclic carbene-catalyzed 4+2, 3+2, 2+2 and 3+3 cycloaddition specially. CONCLUSION The development of the N-heterocyclic carbene-catalyzed annulation reactions provides us new ways and strategies for efficient annulation.