Abstract: OBJECTIVE To study the effect of Kangshen oral liquid on serum urea nitrogen and creatinine levels of acute nephropathy model in rabbits induced by mercuric chloride. METHODS Rabbits were randomly divided into 6 groups of which 5 groups were established as acute nephropathy model, the other group was the control group. The serum was collected and stored in -20 ℃ to determine the serum urea nitrogen and creatinine content. RESULTS Kangshen oral liquid could significantly reduce the level of serum urea nitrogen of acute nephropathy model in rabbits(P<0.01), and it could obviously reduce the level of serum creatinine(P<0.05). The best effect of reducing the levels of serum urea nitrogen and creatinine of acute nephropathy model in rabbits was high dose and medium dose of Kangshen oral liquid. CONCLUSION Kangshen oral liquid can significantly reduce the level of serum urea nitrogen and creatinine.