Abstract: Allergic edema of larynx respiratory tract is the immediate allergic reactions, mainly for the throat submucosal tissue edema, the airway obstruction, patients with inspiratory dyspnea, cyanosis, restlessness, inspiratory laryngeal stridor, serious tone appears complete aphonia, accompanied by other parts of the edema; its many incentives, for drugs, food, insect bite, inhalation ( such as pollen, some chemical gas ) 1. Drug induced laryngeal edema in antimicrobial drugs and herbal incidence is ranked in the top 2; intravenous medication incidence was the highest, and it has nothing to do with age 2; generally occurs in a relatively short time, 30min within 72% 3. Our hospital adverse drug reaction center through the environment, diet, oral medication to exclude, according to the patient's symptoms when judging which of two cases of adverse reactions of intravenous infusion of 12 vitamins cause of drug-induced acute laryngeal edema;