Abstract: OBJECTIVE To observe the importance of clinical pharmacist interventions on Helicobacter pylori positive patients. METHODS Helicobacter pylori positive patients were randomly divided into control or intervention groups according to the disease and age. 219 patients were under study. 88 patients were finished in control and 90 in intervention. Patients in the control group were treated with quadruple chemotherapy for 7 days. The administration accounts were executed by doctors as usual treatment. The intervention group was treated in addition to the above treatment, also the drug education was done by clinical pharmacists and the diary cards were issued. Helicobacter pylori eradication rates of all patients were tested by 14C urea breath test after the end of stopping all medicines 30 days. And telephone follow-up was done at the end of stopping all medicines, after 30 days, half a year and 1 year. RESULTS There was no significant difference in the 2 groups of Helicobacter pylori eradication rates(control 71.59% vs intervention 78.89%), relapse rates of epigastric pain, heartburn, nausea, vomiting and belching, the incidence of adverse reactions. But there were significant differences in the rates of proper use of medications (control 73.86% vs intervention 94.44%) and satisfaction for the treatments (control 78.41% vs intervention 95.56%). CONCLUSION Clinical pharmacist interventions on Helicobacter pylori positive patients improve their proper use of medications and satisfaction to the treatments.