Abstract: OBJECTIVE To introduce the background and current synthesis progress of topiramate. METHODS To review both domestic and international published reports regarding the synthesis of topiramate. RESULTS Made a list of synthesis methods of a key intermediate and four synthesis methods of topiramate including esterification, ammonolysis, catalytic hydrogenation and hydrolyzation and analyzing characteristics of synthesis methods. CONCLUSION The method of ammonolysis provides us a main research direction for efficient synthesis topiramate.