具抗病毒活性的金刚烷胺衍生物的研究进展

Progress of Amantadine Derivatives with Antiviral Activity

摘要: 目的介绍M2离子通道抑制剂金刚烷胺衍生物的研究进展，为设计新的抗流感病毒药物提供相关依据和信息。方法对近年来关具抗流感病毒活性金刚烷胺衍生物、类似物的相关文献进行综述。结果国内外课题组主要集中在金刚烷的1位和2位修饰，合成一系列金刚烷胺衍生物或结构类似物，并进行抗流感病毒活性测试。结论部分金刚烷胺衍生物具有较好的抗流感病毒活性，其中一些化合物的活性优于金刚烷胺和金刚乙胺，这些结果对设计新的抗流感病毒药物具有较好的参考价值。

Abstract: OBJECTIVE To review the research advances in amantadine derivatives with antiviral activity and to provide ideas for research and development of new anti-influenza and anti-virus drug. METHODS Review related literatures about the recent research progress on amantadine derivatives and analogs. RESULTS Many derivatives and analogs of amantadine were synthesized and their anti-influenza and anti virus activities were evaluated. The structural modification focused on the position 1 and position 2 of admantane. CONCLUSION Several active compounds are found, some of which have more potency than amantadine and rimantadine.