Abstract: OBJECTIVE To assess the clinical utilization of antifungal agents to invasive fungal infection during 2009-2011 in Hangzhou area so as to provide evidence for clinical rational usage of antifungal agents. METHODS Antifungal consumption data according to the Hangzhou area of 25 hospitals from 2009 to 2011, the amount of analysis, DDDs analysis, the average daily costs(DDC) analysis were used for statistical analysis. RESULTS The total consumption of antifungal agents in Hangzhou area showed an up trend over the past 3 years, increased by 35.56% and 26.13%, with 108.3% and 78.77% of micafungin, 78.31% and 84% of voriconazole, 58.5% and 70.22% of caspofungin, 18.82% and -14.65% of fluconazole, 7.77% and -33.22% of itraconazole, -3% and -50.01% of amphotericin B. The top DDDs was itraconazole. The top DDC was micafungin. Moreover, the consumption of voriconazole increased rapidly. CONCLUSION The consumption of the antifungal agents in Hangzhou area has increased over 3 years, with negative increase for older products and larger positive increase for newer products. Doctors should pick the antifungal drug by the infected bacteria and microbial sensitivity tests to prevent the spreading of drug resistant bacteria and to prolong the use cycle of the drugs.