Abstract: OBJECTIVE To investigate the clinical efficacy of vinpocetine in treatment of vertigo caused by posterior circulation ischemic. METHODS A total of 74 patients were randomly divided into treatment group and control group, which were treated with Vinpocetine injection and Breviscapine injection, respectively, and evaluated with posterior circulation hemodynamics and hemorheology parameters between pre- and post-treatment. RESULTS Both Vinpocetine injection and Breviscapine injection were effective in treatment of vertigo caused by posterior circulation ischemic. Total effective rates in treatment group and control group were 86.84% and 75.00%. There was no significant difference in the total efficiency rate between the two group, and both had no significant adverse reaction. Intra-group comparisons of both two groups showed that hemodynamics and V_m in posterior circulation were significantly better in pre-treatment compared with post-treatment(P<0.01); inter-group comparisons of both two groups showed that hemodynamics and the Vm in posterior circulation were significantly better in treatment group compared with control group(P<0.01). CONCLUSION Both Vinpocetine injection and Breviscapine injection can be used for the treatment of posterior circulation ischemic vertigo and the advantages of Vinpocetine injection are that it has great effect on the posterior circulation hemodynamics and hemorheology parameters.