Abstract: OBJECTIVE To optimize the extraction process of Compound Surunjiang Dripping Pill. METHODS Orthogonal experimental design was used for optimization, the extract yield, the content of colchicine and aloin were taken as the indexes in extracting process of three herb medicines; the extract yield and the content of polysaccharide were taken as the indexes in extracting process of four herb medicines. RESULTS The optimum extraction progress was as follows: three herb medicines were extracted 2 times for 1 h with 8 times amount of 70% alcohol; four herb medicines were extracted 3 times for 1.5 h with 10 times amount of water. CONCLUSION The optimum extraction process is stable and feasible.