美洛西林钠化学结构的确证

Chemical Structural Confirmation of Mezlocillin Sodium

摘要: 目的建立美洛西林钠化学结构的确证方法。方法通过热分析(TA)、元素分析(EA)、紫外吸收光谱(UV)、红外吸收光谱(IR)、核磁共振(NMR)以及质谱(MS)等分析手段对美洛西林钠样品进行结构分析。结果证实了美洛西林钠的结构为(2S，5R，6R)-3,3-二甲基-6-(2R)-3-(甲磺酰基)-2-氧代-1-咪唑烷甲酰氨基-2-苯乙酰氨基-7-氧代-4-硫杂-1-氮杂双环3.2.0庚烷-2-甲酸钠盐。结论该方法准确可行，可为美洛西林钠的生产和鉴定提供较全面的参考依据。

Abstract: OBJECTIVE To establish a method for the determination of the chemical structure of mezlocillin sodium. METHODS Thermal analysis(TA), elemental analysis(EA), ultraviolet absorption spectrum(UV), infrared Fourier transform spectroscopy(FT-IR), nuclear magnetic resonance(NMR) and mass spectrometry(MS) were adopted to analyze the chemical structure of mezlocillin sodium. RESULTS The chemical structure of mezlocillin sodium was (2S,5R,6R)-3,3-dimethyl-6- (R)-2-(3-methylsulfonyl-2-oxo-imidazolidin-1-yl)carbonylamino-2-phenyl-acetyl amino-7-oxo-4-thia-1-azabicyclo3.2.0 heptane -2-carboxylic acid sodium salt. CONCLUSION The result of the method is accurate, general and can provide a comprehensive reference for production and identification of mezlocillin sodium.