Abstract: OBJECTIVE To investigate the role of clinical pharmacists in anti-infection drug treatment in PICU(Pediatric Intensive Care Unit). METHODS The clinical pharmacists participated in the anti-infection drug treatment of a child patient, formulated the treatment plan together with the clinical doctors and supervised the whole process of treatment for the patient, then adjusted treatment plan according to the patient’s changed condition. RESULTS During the anti-infection treatment, clinical pharmacists provided suggestion such as monitoring the plasma concentration of linezolid that were adopted, which reflected applying of pharmacokinetics and pharmacodynamics theories to guide individualized medicine administration. CONCLUSIONS Clinical pharmacists participation in the clinical treatment and corporation with the clinical doctors to adjust the treatment plan can improve the effectiveness of drug treatment.