Abstract: OBJECTIVE To study the new synthesis technology of isocinazole. METHODS The new technology is begin with 2,2',4'-trichloroacetophenone and after reduction, N-alkylation, etherification and crystallization four-step to synthesis isoconazole. RESULTS The total yield of the reaction reached 47.1%. CONCLUTION The raw materials are easy to obtain and the reactions are simple. This technology provides the rule for industrialization and makes a contribution for the antifungal medicine industry.