Abstract: OBJECTIVE To investigate clinical research progress and its classification by angiogenesis inhibitors target, and provide a reference for a new tumor drug synthesis and discovery. METHODS According to the correlative reports in recent years, angiogenesis inhibitors, especially small-molecule protein-tyrosine kinases(PTK) inhibitors, were discussed about their classification, clinical research and mechanism. RESULTS Angiogenesis inhibitors divided into eight categories, its representative anti-tumor drugs and listed status development was summarized. Furthermore, other applications of the angiogenesis inhibitor were also illustrated. CONCLUSION Compared with traditional chemotherapy drugs inhibiting tumor cell, angiogenesis inhibitors can directly inhibit angiogenesis, so it has a broad prospect in anti-tumor transfer in the future.