Abstract: As the disease with complex symptom and poorly understanding pathology, treatment of systemic lupus erythematous (SLE) is still mainly based on “traditional” drugs, corticosteroids and immunosuppressive. However the mechanism of SLE has been promoted to several levels and provided a brand new clue of target treatment. The research and exploration on biological agents has been put efforts, thus a large number of biological drugs emerged due to regulate the activation of T and B cell through many aspects of immune reaction. The article will present the drugs of each classification and apply an temporary reference for clinical medical therapy guidance.