Abstract: OBJECTIVE To summarize the application progress of process analytical technology in technology innovation of traditional Chinese medicine enterprise. METHODS The relevant articles in recent years were referred and summarized. RESULTS The application and developing tendency of process analytical technology in traditional Chinese medicine manufacture and technology innovation of enterprise were summarized in this paper. Several of technologies including near-infrared spectroscopy and Raman spectroscopy were also introduced. CONCLUSION Process analytical technology will play an important role in the improvement of R&D and manufacturing technology of traditional Chinese medicine.