Abstract: OBJECTIVE To investigate the problems and improvement measures in the children ADR monitoring in our hospital. METHODS Retrospective study was used to analyze 305 cases of ADR reports statistically in 2010-2011, in accordance with the type of report and children's age, gender, weight, as well as drug types, routes of administration, clinical manifestation etc. RESULTS In the 305 cases of ADR reports, the children's average age was (3.16±2.91)years, the average weight was (14.56±8.00)kg, the ratio of male to female was 1.88∶1, children of 0-3 years old accounted for 53.44%; new and severe ADR accounted for 16.39%; most of the ADR was caused by antimicrobial drugs, which accounted for 75.30%; intravenous infusion, the main route of administration, accounted for 95.08%; ADR involving the skin and its appendages as well as digestive system accounted for 80.24%; 46.67% of severe ADR occurred in the medication after 4 d. CONCLUSION In order to do a good job in children ADR monitoring, the necessary facilities must be increased, and practical and feasible management methods must be performed to strengthen the internal management of departments, strengthen training, improve the enthusiasm of the doctors and nurses to report ADR, change the prescription habits of doctors, enhance the understanding on children's psychological and behavior by doctors and nurses.