Abstract: OBJECTIVE To explore information technology management mode of high-alert medications so as to ensure drug safety of patients. METHODS By referring ISMP’s list of high-alert medications, we determined separate single maximum dose and administration route according to package insert etc. Based on hospital information system, we managed drug dose and route information by oracle database and embedded them into doctor workstation. RESULTS & CONCLUSIONS We developed computerized physician order entry of single maximum dose and route on high-alert medications, and reduced the incidence of medication errors.