Abstract: OBJECTIVE To summarize the external function of rhubarb through the experimental study of external use. METHODS Observe the effects of three varieties of rhubarb for external use on rats pedis swelling caused by egg white, auricle tumefaction mice induced by dimethyl benzene, rats traumatic skin ulcer, hemorrhoids in rats induced by 99.0% acetic acid. RESULTS The large and low dose of Rheum palmatum, Rheum tanguticum Maxim, and Rheum officinale Baill significantly inhibited rats pedis swelling by egg white and dimethyl benzene of auricle tumefaction mice, obviously reduced the traumatic skin ulcers area, and promoted skin cutin layer ulcer, squamous cell layer and local pathological organization recovery, and could significantly speed up the rat perianal skin ulcer healing. CONCLUSION External use rhubarb can repair pathological tissue, speed up the uleer area healing, and promote regeneration of tissue for astringency.