Abstract: OBJECTIVE To investigate the local external curative effect of Salviae Militiorrhizae Radix decoction on skin wounds of mice and rats as well as guinea pigs. METHODS The traumatic ulcer models in mice, rats and guinea pigs were established with hydrochloric acid injection, punchering, and Staphylococcus aureus injection, respectively. The effect of Salviae Militiorrhizae Radix decoction on the wound area of mice, rats and the content of lysozyme in the serum of guinea pig along with respective pathological changes were observed. RESULTS The three kinds of model were totally established successfully. After treated with Salviae Militiorrhizae Radix decoction, the wound area of mice and rats reduced remarkably; the content of muramidase in the blood serum of guinea pig increased remarkably; simultaneously the damaged skin repaired remarkably. CONCLUSION External application of the Salviae Militiorrhizae Radix decoction has positive effect on curing skin ulcer of animal models.