Abstract: OBJECTIVE To observe the effect of highly active antiretroviral therapy (HAART) in AIDS patients. METHODS Information about the variations of CD4⁺T lymphocyte, hemogram, biochemical indicators and occurrence of adverse reactions of 90 AIDS patients with HAART from 2004 to 2011 were collected by retrospective survey, then the curative effect of HAART were analyzed. RESULTS The level of CD4⁺T lymphocyte in 90 AIDS patients increased remarkably with the increase of treatment time and was peaked at 24th month(204.32±124.15)mL^-1. The CD4+ T lymphocyte growth were various in different baseline group, the treatment were significantly effective in various periods among group with baseline CD4⁺T below 200 μL^-1(P<0.01), long period treatment (above 6 months) reveals relatively better treatment effect among group with baseline CD4⁺ T lymphocyte above 200 μL^-1(P<0.05). The CD4⁺T increase were different among different baseline groups, ≥200 μL^-1 increased more than the <200 μL^-1 group. There were significant differences in the lymphocyte, hemoglobin, platelets, glucose before and after antiretroviral therapy(P<0.01), but not in the white blood cells, alanine aminotransferase, aspartate aminotransferase before and after antiretroviral therapy(P>0.05). Adverse reactions were most appeared at 3-6 months after treatment. The most frequently occurring adverse drug reactions were appetite changes, nausea, vomiting and rash. CONCLUSION The HAART is effective among 90 AIDS patients. The patients who meet the treatment standard should actively receiving antiretroviral treatment.