Abstract: OBJECTIVE To investigate the effects of Angong Niuhuang pill on serum BNP and CRP and neurological functional defect in patients with acute cerebral infarction. METHODS Totally 136 patients with acute cerebral infarction were randomized into treatment group (70 cases) and control group (66 cases). Both groups were given routine western medicines, the treatment group was given an additional oral administration (or nasal feeding) of Angong Niuhuang pill(1 pill a day) for 7 days. Before treatment and after 30 days’ treatment, each group was graded the neural function defect separately, and before treatment and after 7 days’ treatment, plasma BNP and CRP levels were measured separately. RESULTS After treatment both groups had significant neurological functional improvements(P<0.05), the neurological functional defect was recovered more markedly in treatment group compared with the control group(P<0.05). After treatment, plasma BNP and CRP levels in both groups decreased significantly(P<0.05), which decreased more markedly in treatment group compared with control group(P<0.05). CONCLUSION Angong Niuhuang pill helps to improve neural function in patients with acute cerebral infarction by reducing plasma BNP and CRP levels.