Abstract: OBJECTIVE To optimize the extraction technology of total flavone extraction from Tengligen. METHODS The independent variables were microwave power, ethanol concentration, sample/solvent ratio and extraction time, the dependent variable was extraction rate of total flavone which was used to estimate the relationship between independent and dependent variables. Central composite design and response surface methodology were used to optimize the process of extraction. The prediction was carried out through comparing the observed and predicted values. RESULTS The optimum technological parameters were as follows: microwave power 203.56 W, ethanol concentration 80.34%, sample/solvent ratio of 1∶13.28 and extraction time 9.78 min. The highest extraction rate of total flavone was 103.152 mg·g^-1 which was coincided with model predictions. CONCLUSION The extraction technology is simple, reliable and highly predictive.