利用体内探针法考察植物药和天然产物对人体细胞色素P450和P-糖蛋白活性的影响

Investigation on Modulation of Human Cytochrome P450 and P-glycoprotein by Herb or Natural Product Using in vivo Probe Substrate

摘要: 目的促进植物药和天然产物对人体细胞色素P450和P-糖蛋白活性影响的人体研究的深入，预期临床相互作用，提高合理用药水平。方法综述体内探针法在该领域的国内外的应用。详细介绍应用方法和注意事项。结果国外利用体内探针法的研究较热。鸡尾酒探针法的应用已成熟。结论在我国应大力支持和推广体内探针法在新药研发和临床应用中的研究。

Abstract: OBJECTIVE To promote the in vivo investigation on modulation of human cytochrome P450and P-glycoprotein by herb or natural product, anticipate clinical drug interaction and improve rational drug use. METHODS Literatures using in vivo probe substrate were reviewed. RESULTS Research in this respect abroad is hot. Cocktail methods are widely used. CONCLISIONS In vivo probe substrate phenotying studies should be paid more attention in investigation on modulation of CYP and P-gp by herb and natural products.