GC测定盐酸氟西汀中二氯甲烷残留量

Determination of Residual Dichloromethan in Fluoxetine by GC

摘要: 目的采用气相色谱法检测盐酸氟西汀中的二氯甲烷残留量。方法色谱柱：DB-624毛细管柱(30 m×0.53 mm)；载气：高纯氮气，0.05 MPa；检测器：ECD；进样口温度：150 ℃；检测器温度：300 ℃；柱温为程序升温；进样量：1 μL；分流比：1∶20。结果二氯甲烷在5.96~71.55 μg·mL^-1内，峰面积和浓度之间呈良好的线性关系(r=0.999 6)，3批样品中的二氯甲烷残留量均符合规定(<0.06%)。结论该方法操作简便，精密度好，准确性高，可用于检测盐酸氟西汀中二氯甲烷残留量。

Abstract: OBJECTIVE To detect the residue dichloromethane in fluoxetine by gas chromatography(GC). METHODS Residue dichloromethane in fluoxetine was detected by GC with DB-624 column(30 m×0.53 mm), ECD detector and nitrogen as carrier gas(0.05 MPa). Injector and detector temperatures was set at 150 and 300 ℃ respectively. Column temperature was programmed set. Injection volume was 1 μL and the split ratio was 1∶20. RESULTS Dichloromethane showed a good linear relationship in the range of 5.96~71.55 μg·mL^-1(r=0.999 6), the residue dichloromethane in three batches of samples coincided with the requirements(<0.06%). CONCLUSION Gas chromatography(GC) is simple, accurate, sensitive. It can be used for the determination of dichloromethane in fluoxetine.