Abstract: OBJECTIVE To evaluate the efficacy and safety of combined sucralfate and acid secretion inhibitor. METHODS The Cochrane Central Register of Controlled Trials (Issue 4, 2011), MEDLINE, EMbase, CBM and CNKI (from their inception to November 2011) were searched for relevant studies. Two reviewers independently retrieved randomized controlled trials (RCTs) according to the inclusion and exclusion criteria, assessed the methodological quality of included trials, and extracted data. Meta-analysis was performed by RevMan 4.2 soft. RESULTS Seven RCTs involving 595 patients were ultimately identified. The results of meta-analyses showed combination therapy was not superior to monotherapy in symptom improvement OR 1.6, 95%CI (0.87, 2.93), P=0.13, endoscopic healing OR 1.36, 95%CI (0.87, 2.12), P=0.17 and adverse events OR 1.36, 95%CI (0.64, 2.90), P=0.42. CONCLUSION Combination therapy with sucralfate and acid secretion inhibitor provides no superior in efficacy and safety than monotherapy．