Abstract: To summarize the recently researches of drug-excipients compatibility, in order to help the pharmaceutical dosage formula design. The reasons of the incompatibility of drug-excipients in oral solid dosage forms were analysed at first, then the interactions of drug-excipients were disscused deeply, some research achievements were examplized. The extra-factors which influence the drug-excipients compatibility were disccused. The advanced research methods were summarized to help researches in this field.