Abstract: OBJECTIVE To explore the propess adverse event and treatment. METHODS Adverse events induced by propess during induction of labor in our hospital from January 2008 to December 2010 was studied by retrospective analysis. All of 150 cases of non-propess vaginal delivery was randomly selected as control. RESULTS The incidence of precipitate labor, fetal heart rate abnormal, abnormal uterine contractions in propess group was obviously higher than control. CONCLUSION Although propess causes many adverse events as mentioned above, its effect of promoting cervical to mature is significant. Regulating the use of propess to avoid the incidence of adverse events is important to increase the rate of vaginal delivery and decrease the rate of maternity cesarean section.