Abstract: OBJECTIVE To prepare doxazosine mesylate sustained-release tablets and evaluate the similarity of release property in vitro compared with reference preparation. METHODS HPMC was employed as matrix material and ethyl cellulose aqueous dispersion was used as coating material. The tablets were prepared by wet granule compression method, and the impacts on the release rates with the types of adhesive, the coating formulation and weight gain were examined. After the optimal formula was verified, the test of dissolution in vitro was also researched compared with the reference preparation CarduraXR. RESULTS The release curve was similar to that reference preparation. CONCLUSION The formula of this preparation is stable and simple in technology, and is good in reproduction quality, low in cost and high in production efficiency.