Abstract: OBJECTIVE To prepare and evaluate voriconazole tablets. METHODS The inactive ingredients of voriconazole tablets include pregelatinized starch, lactose monohydrate, croscarmellose sodium, povidone, magnesium stearate. The tablets were film coated. The formulation of the tablets was optimized by an orthogonal design. The hardness, friability and dissolution behavior of the voriconazole tablets was examined and compared with the commercial products. RESULTS The voriconazole tablets contained 40% pregelatinized starch, 21% lactose monohydrate, 3% croscarmellose sodium and 1% magnesium stearate with 5% PVP K90 solution as binder. The hardness was about 15 kg·cm^-2 and the coating level was 4%. The dissolution behavior of the voriconazole tablets was similar to the original products. CONCLUSION The process of preparation is feasible. The in vitro dissolution property of the voriconazole tablets was satisfactory.