Abstract: OBJECTIVE To prepare the enteric microspheres of indapamide and investigate the influencing factors. METHODS Enteric microsphere of indapamide was prepared by emulsion solvent diffusion method using hydroxypropyl methylcellulose phthalate(HPMCP) as an enteric polymer. The formulation of the microspheres, recovery, drug loading, encapsulation efficiency and the releasing characteristic of microspheres in vitro were investigated. RESULTS The microspheres were spherical and smooth in appearance, bridging agent and emulsifying agent were the main factors affecting the formation of microspheres. The drug loading and encapsulation were 14.85% and 76.30%, respectively. The cumulative release of drug in simulated intestinal fluid met the requirements and the amount of carrier material controlled the drug release rate. CONCLUSION This method is suitable for preparation of enteric microspheres of indapamide, the technology is simple and the release characters is good in vitro.