Abstract: Fibrates are a group of agents commonly prescribed for dyslipidemia to prevent atherosclerosis and cardiovascular events in clinic by their action to lower triglyceride. Their indications include hypertriglyceridemia and mixed hyperlipidemia. However, they have been widely reported to cause myotoxicity, including typical fetal rhabdomyolysis. Here, we comprehensively reviewed research progress of myotoxicity caused by fibrates, to help reduce clinical risk and lay a good basis for mechanism investigation.