Abstract: OBJECTIVE To compare the two different extracting methods:the CO₂-SFE and the alcohol refluxing method, on extraction of Corydalis Rhizama and Angelica dahuricae Radix. METHODS TLC, HPLC were used to determine the extracting efficiency with the active components yield; the analgesic experiments were used to explore the differences in the analgesic effect between the two extraction methods. RESULTS CO₂-SFE had 1/4 extract yield of refluxing method, but its purity was 6-9 times higher than refluxing method. It had better analgesic effect in the experimental models and had better effects on pain-related substances. CONCLUSION To extract Corydalis Rhizama and Angelica dahuricae Radix by SFE is more efficient and feasible than the traditional alcohol refluxing method.