Abstract: OBJECTIVE To investigate the general information and characteristics of adverse drug reactions (ADRs), and provide reference for rational drug use in clinic. METHODS There were 1 141 ADR cases collected in our hospital in 2008-2010, which were retrospectively analyzed in respect of gender, age, types of adverse drug reactions, categories of drug, classification of serious degree of adverse drug reactions. RESULTS Of the 1 141 ADR cases, the incidence rate in female (652 cases, 57.14%) was higher than that in male. The elder people were higher. Intravenous drip and the oral administration accounted for 48.32% and 47.70%, respectively. Anti-infectious drugs (52.46%) occupied mostly in the incidence of ADRs. Lesions of skin and its appendants were the main clinical manifestations. Most ADRs were cured or got better. CONCLUSION More importance should be attached to the monitoring of ADRs. Observation of patients during drug use should strengthen to reduce or avoid the occurrence of ADRs.