Abstract: OBJECTIVE To introduce the progress of the novel gastroretentive drug delivery system, and provide the reference for study on gastroretentive dosage form. METHODS Look up the related references published in home and abroad in recent years, then analyze, arrange and sum up them. RESULTS The novel gastroretentive drug delivery system can increase the absorption and bioavailability of drugs, and the researches on floating drug delivery system, mucoadhesive drug delivery system and expandable drug delivery system are widely studied. CONCLUSION With the further study on gastroretentive drug delivery systems and the development of novel high polymer materials and new technology, this formulation will has wider application prospects.