Abstract: OBJECTIVE The effects of quercetin on quantitative changes of urine and uric protein in rats with experimental chronic renal failure were studied. METHODS The rats in control and treated groups were fed with 0.75% adenine for 2 months to build up chronic renal failure modle; and the quercetin were administered orally (100 mg·kg^-1·d^-1) for 42 days to the rats in treated group. The quantities of 24 h urine and uric protein were determined weekly. RESULTS The renal indexes, water percentages of renal tissue, serum CREA and BUN levels in treated group decreased significantly when compared with those in control group (P＜0.001). The 24 h urine volume in treated group increased (P＜0.001), and 24 h uric protein decreased (P＜0.001) significantly than those in the control group. CONCLUSION Qercetin is effective in preventing and curing of chronic rend failure in rats.