Abstract: OBJECTIVE To optimize the extraction process of Compound Xuelian Cataplasm. METHODS Orthogonal experimental design was used for the optimization, the extract yield, the content of osthole and curcumin were taken as the indexes in extracting process of seven herb medicines; the extract yield and the content of gallic acid were taken as the indexes in extracting process of two herb medicines. RESULTS The optimum extraction progress was as follows: seven herb medicines were extracted 3 times for 1 hour with 10 times amount of 80% alcohol; two herb medicines were extracted 3 times for 2.5 hour with 10 times amount of water. CONCLUSION The optimum extraction process was stable and feasible.