制剂增溶技术中高分子聚合物对难溶性药物释放性能的影响

Effects of Polymers on Insoluble Drug Release in Solubilization Technique

摘要: 目的综述制剂增溶技术中高分子聚合物对难溶性药物释放度的影响，为实际应用提供参考。方法在查阅国内外相关文献的基础上，对制剂技术中高分子聚合物的加入对难溶性药物释放的影响进行分析和总结。结果高分子聚合物的类型、性质、药物在聚合物中的存在状态、结合方式以及聚合物与其他辅料的配伍等因素均能影响难溶性药物在制剂中的释放。结论高分子聚合物与难溶性药物从制剂中的释放有必然的联系。

Abstract: OBJECTIVE To study the effects of polymers on insoluble drugs in solubilization technique and to provide the reference for the practical application. METHODS On the base of extensive literature all over the world, the effects of polymers on the release of insoluble drugs were analyzed and summarized. RESULTS Preparation method, dosage of polymers and type of polymers had a certain impact on the release mechanism of insoluble drugs. CONCLUSION Polymers on the release of insoluble drugs have a great impact.