Abstract: OBJECTIVE Preparation and formulation investigation of asiaticoside orally disintegrating tablets. METHODS Prepare the tablets by using asiaticoside as principal drug and starch as disintegrating agent; establish the quality control method including character, disintegration, assay etc. RESULTS The asiaticoside orally disintegrating tablets prepared met technology requirements. The assay of asiaticoside was determined by HPLC, average recovery rate and RSD were 100.7% and 1.01% (n=9) respectively. CONCLUSION The preparation technology is feasible and testing method is convenient and accurate.