Abstract: OBJECTIVE To optimize the process conditions of Cassiac torae pellets by extrusion-spheronization and fluid bed coating technology. METHODS L₉(3⁴)orthogonal design was used to obtain optimal process conditions of Cassiac torae pellets by extrusion-spheronization technology. Micromeritics of the pellets was determined. The pellets were coated by fluid bed coating technology. Their dissolution profiles were tested in vitro. RESULTS The optimal formulation and process condition of Cassiac torae pellets prepared by extrusion-spheronization were as follows: MCC as the main excipient, 40% drug loading，spheronization velocity being 50 Hz;spheronization time being 4 minutes,extrusion velocity being 30 Hz.The obtained pellets were round,smooth and even. The cummulative drug release in vitro was more than 99% within 60 minutes. CONCLUSION The process of preparing Cassiac torae pellets by extrusion-spheronization and fluid bed coating machines was simple and quick with excellent quality and yield of pellets.