四-(三氟乙烷氧基)酞菁锗的光物理性质研究

Photophysical Properties of Tetra (trifluoroethoxy) Phthalocyaninate Germanium

摘要: 目的研究四-(三氟乙烷氧基)酞菁锗(GePcF)的光物理性质，评价其在光动力疗法(PDT)中的应用价值。方法采用紫外-可见分光光度计测定GePcF的吸收光谱和摩尔消光系数；应用9,10-二甲基蒽(9,10-dimethylanthracene，DMA)为捕捉单线态氧的探针，首次采用高效液相色谱法(HPLC)测定光照过程中DMA浓度的变化，从而计算GePcF的单线态氧量子产率。结果 GePcF的摩尔消光系数为1.36×10⁵ L·mol^-1·cm^-1，单线态氧量子产率为0.61。结论 GePcF有较高的摩尔消光系数和单线态氧量子产率，具备作为PDT光敏剂的性质要求，有进一步研究其抗肿瘤效果的前景。

Abstract: OBJECTIVE To evaluate the potential opplication of tetra(trifluoroethoxy) phthalocyaninate germanium (GePcF) by determining its photophysical properties. METHODS The UV-Vis spectrometer was used to measure the UV-Vis spectrum and molar extinction coefficient of GePcF. The concentration variation of singlet oxygen probe-9,10- dimethylanthracene (DMA) was first measured by HPLC to calculate the singlet oxygen quantum yield of GePcF. RESULTS The molar extinction coefficient was 1.36×10⁵ L·mol^-1·cm^-1 and the singlet oxygen quantum yield was 0.61. CONCLUSION　GePcF shows very high molar extinction coefficient and high singlet oxygen quantum yield. Both properties are needed as PDT photosensiter and GePcF has promising anti-tumor prospects for the further research.