Abstract: OBJECTIVE To analyze the effect of misoprostol and primacaine in artificial abortions. METHODS Two hundred cases were randomized into observation group and control group, 100 cases in each group. In the observation group, 600 μg misoprostol was orally administered 4 hours before the surgery, and 1.7 mL primacaine was injected at point 3 and point 9 of the mystera 2 minutes before the vaccum aspiration surgery. In the control group, 600 μg misoprostol was orally administered 4 hours before the surgery, without application of the primacaine. RESULTS In the observation group, none of the 100 patients reported pain in the whole procedure of the surgery. In the control group, 15(15%) patients reported moderate pain; 73(73%) patients reported mild pain; and 12(12%) patients did not report experience of pain. In the observation group, No.7 cervical dilator could be directly inserted in 98(98%) patients and No.6 cervical dilator could be directly inserted in 2(2%) patients. In the control group, No.7 cervical dilator could be directly inserted in 97(97%) patients and No.6 cervical dilator could be directly inserted in 3(3%) patients. Compared with the control group, operation time was significantly shortened, and the amount of bleeding was significantly reduced(P<0.05). No PASS occurred in the observation group and 3 cases of PASS occurred in the control group. CONCLUSION Primacaine combined with misoprostol can effectively loosen the cervix, thus prevent the pain in the surgery and the occurrence of artificial abortion syndrome. It can reduce the amount of bleeding and shorten the operation time. Therefore it is appropriate to be promoted and applied in primary hospitals.