三七皂苷缓释微球的性质研究

Study on the Properties of Panax Notoginseng Saponins Sustained Release Microspheres

摘要: 目的对三七皂苷缓释微球(PNS-SRM)的理化性质进行研究。方法采用粒径测定、扫描电镜(SEM)、比表面积测定、差示扫描量热分析(DSC)、红外光谱(IR)、X射线衍射(XRD)、溶出度测定等手段研究PNS-SRM的理化性质。结果 PNS-SRM与物理混合物相比，在IR、DSC、XRD上有显著差异。PNS-SRM具有明显的缓释效应。结论 PNS-SRM中壳聚糖、丙烯酸树脂和三七皂甘(PNS)之间发生了分子间作用，有新晶形生成。

Abstract: OBJECTIVE To study on physicochemical properties of Panax notoginseng saponins sustained release microspheres (PNS-SRM). METHODS Some analytical methods, such as determination of particle size, scanning electron microscopy (SEM), differential thermal analysis (DSC), infrared spectra (IR), X-ray powder diffraction (XRD), specific surface area determination, dissolution test, were applied to the investigation of PNS-SRM. RESULTS There were difference between PNS-SRM and physical mixture in IR, DSC, XRD. The PNS-SRM had good slow releasing effect. CONCLUTION There is intermolecular interaction among chitosan, acrylic resin and PNS in PNS-SRM. In the PNS-SRM a new crystal form was generated.