丹酚酸A中树脂残留溶剂的测定

Determination of Residues from Macroporous Adsorbing Resins in Salvianolic Acid A

摘要: 目的建立丹酚酸A中树脂残留溶剂正己烷、甲基环己烷、苯、甲苯、二甲苯、苯乙烯、二乙烯苯的测定方法。方法采用顶空毛细管气相色谱法进行测定，色谱柱为HP–1701毛细管柱；程序升温，初始温度为40 ℃，保持3 min后，以8 ℃·min^-1升温至140 ℃；FID检测器。结果线性关系良好(r>0.999)，回收率在96.53%~99.32%之间。结论本法简便、准确，适用于丹酚酸A中树脂残留溶剂的测定。

Abstract: OBJECTIVE To establish a method for detecting the residues, including hexane, methylcyclohexane, benzene, toluene, xylene, styrene, diethylbenzene divinybenzene, from macroporous adsorptions resin in salvianolic acid A. METHODS Headspace GC was adopted using an HP-1701 capillary column and hydrogenflame ionization detector. The initial temperature was 40 ℃ maintained for 3 min and then raised (8 ℃·min^-1) to 140 ℃. RESULTS There was favorable linearity relation between peak area and concentration in the observed concentration range(r>0.999). The average recovery was in the range of 96.53%–99.32%. CONCLUSION The method is simple, accurate and specific. It can be used for the determination of residues from macroporous adsorbing resins in salvianolic acid A.